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Vitamin C is the best-studied and understood antioxidant: a substance that readily donates electrons to neutralize potentially damaging oxidative free radicals. As our cells use oxygen to make energy, they create oxygen free radicals, which must be tightly controlled or they can destroy DNA, proteins, and other key cell components

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The dimerized TM conformation further indicates that the two intracellular kinase domains are positioned in proximity for trans-autophosphorylation (Supplementary Fig