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The condition was assessed solely through clinical observation, without distinguishing between different subtypes based on pigment depth or morphological patterns

SAM, SAH, methionine and homocysteine A plasma methylation panel gives more direct information about methyl supply, methylation inhibition and methionine-cycle dynamics

GLP-1R is expressed in dorsal root ganglion (DRG) neurons 40 and could explain the potential direct effect on pain in OA since DRG neuron endings are present in the synovium 41

Convergence with Combination Biology Dual and multi-agonist molecules combining GLP-1 activity with GIP and/or glucagon receptor activity are emerging and driving superior metabolic efficacy in clinical studies