The adverse effects associated with this compounded medication primarily reflect those observed with semaglutide, as cyanocobalamin is generally well-tolerated with minimal side effects when administered at therapeutic doses
A small amount of the ingested vitamin B12 (one to two per cent) is absorbed by passive diffusion simply crossing the cell membranes without binding to anything (Temova Rakua et al., 2022)
In turn, this may contribute to the development of depression by increasing oxidative stress, DNA damage, and cell death in the body ( A 2020 study with 132 children and teens, 89 with and 43 without depression, found that the participants with depression had lower B12 levels and higher levels of homocysteine compared with those without depression ( In addition to depressive symptoms, low or deficient B12 levels may lead to other mental conditions, including psychosis and mood disorders ( Because a deficiency in B12 negatively impacts the central nervous system, people with low or deficient B12 levels may feel foggy-headed and have difficulty concentrating and completing tasks ( Fortunately, studies show that mental impairment related to low B12 levels can improve with B12 treatment
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10.1016/j.clinthera.2011.03.003 [DOI] [PubMed] 29.Kuzminski AM, del Giacco EJ, Allen RH et al (1998) Effective treatment of cobalamin deficiency with oral cobalamin