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This is due to the diversity of models used varying in species, strains, genetic background, sex, age, study design, duration, and especially the methods of disease induction (Chua et al

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The model of an ethanol-induced gastric ulcer is used for the evaluation of the gastroprotective activity of many new therapeutics and natural products [5]

Also, the oxidized form of heat shock protein 70 is incapable of transporting TDP-43 back to the nucleus