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GIP receptor activation enhances insulin secretion, improves fat metabolism, and may contribute to central nervous system effects on appetite that go beyond what GLP-1 alone can achieve

Increasing access will require addressing the significant barriers to care, such as treatment cost, site of care, and the policies that insurance plans can implement, such as step therapy and prior authorizations. For the study, the team used national insurance claims data for more than 97,000 commercially insured US adults diagnosed with obesity, but not diabetes, between June 2021 and July 2022

When medications are tolerated more comfortably, dose adjustments become easier to sustain over time, which is important for long-term metabolic outcomes

Next-generation GLP-1 drugs Retatrutide , the triple agonist, could become the most potent weight loss and glucose-lowering medication ever developed

Otherwise, try a stool softener such as Colace or Senna