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According to the results of the Rosetta Cartesian_ddG and Flex_ddG, we manually checked the PV2 and PV3 variants predicted to be highly stable, exhibit low binding free energy and are located outside the CDR regions, and those having pAcF facing outward were selected for experimental characterization, including PV2 variants S8pAcF, S26pAcF, S71pAcF, S74pAcF, Q82pAcF, S85pAcF and PV3 variants S8pAcF, S26pAcF, S71pAcF, N77pAcF, S85pAcF, K87pAcF (Fig

Some metabolic enzymes, such as succinate dehydrogenase (SDH), fumarate hydratase (FH), IDH and pyruvate kinase 2 (PKM2) are likely to activate HIF-1 pathway by stabilizing HIF-1, therefore enhancing cancer metastasis (258)

Differential gene expression analysis was conducted using DESeq2 (v1.20.0), with P values adjusted by the Benjamini-Hochberg method

(2017) recently submitted works utilising BPC 157 for the treatment of inferior caval vein ligatures and colitis in rats, respectively

The endotoxin hypothesis of Alzheimers disease