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Indoxyl sulfate, a uremic toxin, stimulates reactive oxygen species production and erythrocyte cell death supposedly by an organic anion transporter 2 (OAT2) and NADPH oxidase activity-dependent pathways

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This is manifested by an increase in the phylum Bacteroidetes and eight specific genera, namely Bacteroidales S24-7, Ruminococcaceae , Parabacteroides , Butyricimonas , among others, as well as a decrease in the abundance of the Lactobacillus and gauvreauii genera