Combinations with GLP-1 RAs Several clinical trials have shown significant CV benefits of GLP-1 RAs in patients with T2D who were at high risk of CV events, with many of these individuals also taking a RAAS inhibitor at baseline [27, 36,37,38]
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Preclinical research in animal models has identified GLP-1 receptors in synovial tissue, cartilage, and bone, suggesting potential for direct effects on joint structures
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