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By this delivery method, HGF improves angiogenesis, decreases oxidative stress, enhances synaptogenesis, and increases BDNF levels in the brain of AD mouse model (Takeuchi et al., 2008)

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doi: 10.1038/s41598-020-65269-6

Moreover, after intervention, thoracic aorta contraction is reduced and relaxation response to SNP is enhanced in T2DM rats, suggesting that the protective effect of BBR on diabetic macrovascular complications is related to inhibition of inflammation and intervention of potassium channels