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The primary explanation for this drug interaction seems to be a reduction in enterohepatic circulation of valproic acid
[DOI] [PMC free article] [PubMed] [Google Scholar] 82.Akintola A.A., van Opstal A.M., Westendorp R.G., Postmus I., van der Grond J., van Heemst D
This mechanism holds the highest translational value due to consistent human data and well-defined molecular targets [e.g., competition with arachidonic acid for COX/LOX enzymes (84)]
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