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In each case, patients can then resume their regular once weekly dosing schedule

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At the beginning of the study, some patients used metformin, insulin, sulfonylureas, or iSGLT2, in addition to antihypertensive, hypolipidemic, and antiplatelet or antithrombotic agents [44]

Hedgehog signals mediate anti-cancer drug resistance in three-dimensional primary colorectal cancer organoid culture