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CpG oligonucleotide, a TLR9 agonist, enhanced the antitumor potential of macrophages by increasing FAO and shunting of acetyl-CoA toward lipid substances synthesis, which needed the involvement of CPT1A and ATP citrate lyase (Liu et al., 2019)

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Because peptides are short chains of amino acids that act as signaling molecules, BPC-157 appears to act on the tissues of the digestive tract and more broadly throughout the body