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Its selectivity for NNMT (IC50 values in the low micromolar range) means it increases NAD+ by preserving nicotinamide availability rather than directly supplementing NAD+ precursors

However, as Moncrieff and colleagues point out in an attractive systemic review, there is no convincing evidence that depression could be associated with or caused by lower serotonin concentrations or activity [94]

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For CD terms between three months and one year, the penalty is three months of interest