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IGF-1 is a major downstream mediator of GH-axis activity and is involved in anabolic signaling, tissue remodeling, and metabolic regulation. In healthy-adult studies, CJC-1295 with DAC produced sustained increases in both GH and IGF-1. These data apply specifically to the long-acting DAC-modified form, but they help explain why CJC-1295-class peptides are used to study GH/IGF-1 pathway activation

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