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The idea is that phosphorylated uncoupled MOR accumulates at the cell surface when dephosphorylation and recovery from desensitization requires endocytosis (Schulz et al., 2004)

Investigated for roles in tissue regeneration and musculoskeletal recovery

Moreover, simplified experimental paradigms often fail to capture the complex, multifactorial nature of human neurodegeneration, including chronic inflammation, metabolic dysfunction, and cumulative injury [569571]

Calcium signaling and neurodegenerative diseases

All were determined in the presence of bound antagonist or inverse agonist, and in the absence of associated G protein, so likely represent inactive conformations