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For patients who cannot achieve appropriate glycemic control with 30-mg albiglutide, the dose can be increased to 50 mg once weekly, which has been shown to result in improved glycemic control1)

However, the delivery of BACE1-targeting small interfering RNAs (siRNAs) to the brain remains a major challenge due to the BBB and the protective membranes surrounding neurons

The SASP damages surrounding tissue, drives chronic inflammation, and converts neighboring healthy cells into senescent ones (van Deursen, 2014)

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However, it is important to note that erythrocytes generate ROS primarily as a result of (i) hemoglobin oxidation, which can be considered as an iron-mediated Fenton reaction, (ii) the activity of NAPDH oxidase and (iii) xanthine oxidoreductase, while in nucleated cells ROS are mainly generated in the mitochondrial electron transport chain