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The main safety concern is in dogs with active cancer, as TB-500 promotes cell growth and blood vessel formation

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It causes the proliferation of white blood cells and regulates antibody production by B cells, thymulin secretion by the thymus, and natural killer, engulfment (phagocytosis), and oxidative burst capacity of white blood cells (neutrophils and macrophages) [25, 26]

Across all clinical trials, the side effect profile was consistently described as indistinguishable from placebo

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