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Elevated homocysteine has been associated with skin changes including hyperpigmentation, and some research connects poor methylation status to inflammatory skin conditions

Tang-Christensen, M

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Kore said that the toxicity of vitamin B12 can be treated by giving more hydration orally or through an IV line, depending upon the severity of the symptoms

Specific pathways affected include TGF-beta superfamily signaling, Wnt signaling, antioxidant defense (including superoxide dismutase, glutathione S-transferases, and thioredoxin reductase), and DNA repair mechanisms