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Tirzepatide produces greater weight loss in clinical trials, with patients losing an average of 22.5% of body weight compared to 14.9% with semaglutide
However, like all medications, they come with potential side effects, particularly affecting the gastrointestinal system
Real-world data with behavioural support Second Natures peer-reviewed research, published in JMIR Formative Research (2025), showed that semaglutide, combined with registered dietitian support and a structured behaviour change programme, produced an average 19.1% weight loss at 12 months, with 77.7% of participants achieving at least 10% weight loss
When to Seek Medical Advice Most missed doses are not medical emergencies
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