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Important safety considerations include a boxed warning for medullary thyroid carcinoma (MTC) risk with most GLP-1 medications, which are contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

5.1.5 Stem cell and exosome-based therapies Mesenchymal stem cells (MSCs) have emerged as promising agents in OA therapy due to their immunomodulatory, antioxidative, and chondrogenic capacities

Similarly, beta-lactams and fluoroquinolones, the first-line antibiotics, have been found to play a significant role in the AMR burden globally 33,34

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