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References Jensterle M, et al

Ethics declarations Competing interests The authors declare that the Monell Chemical Senses Center has filed a patent application related to potential therapeutic compounds

In patients with Parkinsons disease, consumption of caffeine for 6 weeks in doses of at least 200 mg/day was associated with an improvement in motor symptoms, and a slowing of the progression of dyskinesia was observed [60,61]

For instance, in a study involving human breast cancer cells treated with GPS, researchers observed an elevated Bax/Bcl-2 ratio, caspase activation, and a marked increase in apoptotic cells ( 4.6.2 Inhibition of tumor cell proliferation and migration Beyond its role in apoptosis induction, GPS exhibits significant inhibitory effects on tumor cell proliferation and migration, both of which are critical mechanisms driving cancer progression

The Phase 2 data proved that starting higher doubles GI side effects with no benefit to long-term outcomes