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Allison KC, Chao AM, Bruzas MG, McCuen-Wurst C, Jones E, McAllister C, Gruber K, Berkowitz RI, Wadden TA

However, alcohol interacts with the other B vitamins that B12 needs to do its jobs

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These mitochondrial alterations are accompanied by changes in nuclear-encoded mitochondrial gene expression, suggesting epigenetic regulation of cellular energy metabolism pathways (49)

Through the synaptic NMDA pathway (the N-methyl D-aspartate pathway), PQQ can help modulate the excitatory activity of glutamate and is highly regarded for its role in maintaining neuronal health which can thus promote overall cognitive function