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Generally, the ectopic overaccumulation of lipids can trigger cellular dysregulation and functional tissue impairment, a process referred to as lipotoxicity (1)
Sin una cantidad suficiente de L-carnitina, este proceso se ve comprometido, lo que puede llevar a una menor oxidacin de grasas y a una acumulacin de lpidos en el citoplasma de las clulas
and submission of at least one PRO survey using a Fine-Gray subdistribution hazard model to account for the competing risk of death without survey submission
Indeed, it is known that thanks to KD patients with T2DM can reduce and stabilise glucose levels (fasting, after meals and throughout the day), lower HbA1c and insulin levels, reduce body weight, and reduce (or even wean off) diabetes medication, often achieving full remission
Because of the overexpression of the transgene, the complementation efficiency of the CS substitution variants of GSAAT1 could not be assessed
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