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Aging Cell 20(11):e13507

In UC, COX-2 expression is elevated in the mucosal epithelium and crypt, where it increases PGE2 expression through the NF-B signaling pathway

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GLP-1s role in neuroprotection: a systematic review

The mechanism involves Kir4.1 that facilitates the clearance of extracellular potassium (K+), leading to a decrease in extracellular K+ concentration, which directly influences the resting membrane potassium (RMP) of neurons, leading to hyperpolarization of neurons, and activates calcium channels that promote bursting, ultimately affecting monoaminergic centers involved in the pathophysiology of depression [150]