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The authors concluded that supplementation of HA to collagen did not improve various skin parameters, and therefore, the dermal benefits of the HA active ingredient could not be confirmed in this study [53]

In rats given BPC-157, serotonin levels in the brain increase in specific regions while simultaneously decreasing in other regions, such as the hippocampus.[ref] A 2020 study found that BPC-157 reduced leaky gut syndrome by stabilizing gut permeability after NSAID use.[ref] Reducing leaky gut theoretically can affect the gut-brain axis and reduce inflammation

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