Inherited disorders of vitamin B 12 absorption Rare cases of inborn errors of vitamin B 12 metabolism have been reported in the literature (reviewed in 6)
Additional caution or monitoring may be appropriate in research settings involving: Active cancer- or tumor-related research models, where antioxidant-related pathways may influence cellular-response or treatment-response mechanisms Severe asthma or hypersensitivity-prone research models, as rare sensitivity-related observations have been reported in some experimental contexts Sulfur-sensitive research models, due to Glutathione containing a thiol (sulfur-containing) group Complex hepatic-function or detoxification-related investigations, where antioxidant modulation may influence oxidative-stress or liver-related biomarkers Research conditions, research amounts, protocol duration, administration frequency, and concurrent compounds may influence tolerability observations across experimental settings
While many clients report positive effects, its important to note that scientific evidence for some wellness uses is still emerging
Neuro endocrinology letters, 23(4), 365368
The First Placebo-Controlled Trial of a Special Butterbur Root Extract for the Prevention of Migraine: Reanalysis of Efficacy Criteria
