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In summary, IR disturbs the function of the vascular endothelium and weakens the anti-hypertensive effect of insulin

It is very common in developing countries like India, but it is more prevalent in poor communities

In midbrain areas, such as the substantia nigra and ventral tegmental area, insulin upregulates dopamine transporter expression and reduces excitatory glutamatergic input, decreasing extracellular dopamine levels [90]

10.1371/journal.pntd.0004268

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