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Small molecule programs remain high risk high reward Pfizers pullback from its own oral GLP-1 programs has highlighted a major scientific challenge: biased agonism can improve GI tolerability but does not eliminate hepatotoxicity risk

Mullins RJ, Mustapic M, Chia CW, Carlson O, Gulyani S, Tran J, et al

GLP-1 Receptor Agonist Use and Risk of Suicide Death

"Reprogramming to recover youthful epigenetic information and restore vision" As detailed in this landmark study published December 2, 2020 in Nature, Professor Sinclair and colleagues have used epigenetic reprogramming to reverse vision loss in aged mice afflicted with glaucoma

Tibial cortical thickness decreased by 1.8% (p = 0.012) in the semaglutide group