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However, this distribution strategy was obviously unsuitable for regular clinical use due to the short half-life of the drug

An 8-week study from 2000 in 27 college football players observed that taking a ZMA supplement daily significantly increased free testosterone by 33.5% and insulin-like growth factor 1 (IGF-1) levels by 3.6%

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It means you and your health care provider need to watch for changes in thyroid levels or symptoms and adjust as needed