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ROS can induce single-strand and double-strand breaks in sperm DNA, as well as the formation of oxidative base lesions such as 8-hydroxy-2-deoxyguanosine (8-OHdG) (33, 34)

All samples were collected under Institutional Review Board-approved protocols (STUDY61977 and STUDY7108), and all participants provided written informed consent

Vitamin C and Niacinamide can be used together safely

Production of PIP 3 enables phosphorylation of Akt at threonine 308 (T308) by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and at serine 473 (S473) by the mechanistic target of rapamycin complex 2 (mTORC2)