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[1] The gastrointestinal side effects of tirzepatide, particularly nausea, vomiting, and diarrhea, can sometimes be accompanied by systemic symptoms such as weakness, lightheadedness, or body discomfort

The inhibition of the onset and progression of DKD is an urgent issue, and the development of therapeutic approaches against DKD is required

Our findings broadly support the advice to discontinue GLP-1 agonists and SGLT2 inhibitors during pregnancy and lactation, and also support the ongoing registration of pregnancy outcomes in pharmacological databases since the amount of available data is scarce and mostly limited to animal studies

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