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An association with vitamin B 12 deficiency in non-metformin-exposed individuals and genotype was also demonstrated for both AG (OR 1.11 [95% CI 0.99, 1.24], I 2 =19.3%) and AA (OR 1.42 [95% CI 1.21, 1.67], I 2 =14.4%) genotypes but ORs were lower than in metformin-exposed individuals

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