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(I) The relevant mechanisms involved in each step of the intracellular GSH exhaustion process need to be further explored, and the biological effect of cancer cells after GSH depletion remains to be elucidated

While its ability to influence multiple pathways of repair is supported by compelling preclinical data, the absence of high-quality human trials, the FDAs strict regulatory stance, and the risk of contamination from unregulated sources raise serious safety and legal concerns (including malpractice concerns and fines)

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When these enzymes are insufficient, vitamin B12 cannot be processed and absorbed normally

e and f , Levels of guanidoacetate m + 2 in liver (e) at 45 min and urine (f) at 2 h in Het or KO mice