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We then limited the dataset to the hospitals with CY 2024 claims data that we used to model the impact of the proposed CY 2026 APC relative payment weights (3,388 hospitals) because we believe it is appropriate to use the same set of hospitals that are being used to calibrate the modeled CY 2026 OPPS

Importantly, GLP-1 and glucagon act through structurally related receptors and both peptides exhibit similar amino acid N-terminal sequences, a domain essential for proper interaction with their receptors

That has, in part, driven the gray market for peptides from questionable sources

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So the third mechanism of action is around slowing stomach emptying and slowing what we call gastric emptying that process leaves food in the stomach for longer therefore there is less necessity to go looking for food and finally, the action is around the effect on the pancreas where GLP-1s both increase the amount of insulin that is produced as well as increase the amount that is released