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These observations suggest that the timing of metformin administration can potentially substantially influence its efficacy for postprandial glucose-lowering, and that the current recommendation (at least for the immediate-release preparation) that people with type 2 diabetes should take metformin with meals may compromise its benefits

Every benefit attributed to it is inferred from component data, and the inference has never been validated for the combination

DOI: 10.4088/JCP.23m15068

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