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6 Department of Pathology, Binzhou Medical University Hospital, Binzhou, Shandong, Peoples Republic of China

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In breast cancer, where EGFR inhibitors such as erlotinib are being used to inhibit the EGFR signaling pathway, IGF-1R confers resistance by forming one half of a heterodimer (see the description of EGFR signal transduction in the erlotinib page), allowing EGFR signaling to resume in the presence of a suitable inhibitor

The side effect pattern continues with a few days of increased nausea after the first 10 mg dose, then improvement

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