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Reported benefits for deficient or lownormal individuals can include: Increased energy and reduced fatigue

J Thorac Oncol 5(8):11201129 Tolkach Y et al (2019) Apelin and apelin receptor expression in renal cell carcinoma

Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)