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Prevention focuses on nutrition, gradual weight loss, and clinical evaluation when needed

Emerging therapies and future drug prospects DN is a complex and multifactorial complication of diabetes mellitus, often progressing despite optimal glycemic control

When the gut barrier is compromised, it allows lipopolysaccharides (LPS)toxic structural components found on the outer membrane of gram-negative gut bacteriato "leak" or translocate from the intestinal lumen directly into the bloodstream

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The jagged-2/notch-1/hes-1 pathway is involved in intestinal epithelium regeneration after intestinal ischemia-reperfusion injury