In 2017, subcutaneous semaglutide was approved for once-weekly administration [23], becoming only the second approved once-weekly GLP-1RA (after dulaglutide)
Tirzepatide May Be Right for You If: You have overweight or obesity with significant visceral (belly) fat You struggle with severe insulin resistance or type 2 diabetes Your weight gain is linked to hormonal or metabolic imbalance (PCOS, metabolic syndrome) You have tried Semaglutide or similar treatments without satisfactory results You experience plateaus despite diet and exercise You need stronger appetite suppression plus metabolic fat reduction Best for: Patients who need more powerful, dual-action support for stubborn fat, blood-sugar control, and faster metabolic improvement
Semaglutide lowers blood sugar, and when blood sugar levels are reduced, the body adjusts in different ways
doi:10.1001/jama.2023.12055
Significance of FDA Approval Sally Seymour, M.D., director of the Division of Pulmonology, Allergy and Critical Care at the FDA, underscored the significance of this landmark decision, noting that it introduces the first drug treatment option for certain patients with OSA