what tirzepatide and Semaglutide key differences, weight loss results (2026) How Does Tirzepatide Work? |

In clinical trials, this produced an average weight loss of 22.5% of body weight over 72 weeks

Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus (brand name Mounjaro) and chronic weight management (brand name Zepbound) in adults with a BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity

Common side effects include nausea, diarrhea, decreased appetite, and vomiting

Comparing Semaglutide and Tirzepatide Effectiveness When deciding between Tirzepatide or Semaglutide, effectiveness matters

Extremely common