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CD8 + cytotoxic T lymphocytes mediate direct thyrocyte lysis via perforin, granzymes, and proteoglycans, and are recruited and activated by autoreactive CD4 + T cells through IL-12 and IFN- signaling

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Moreover, the nanoDSF-derived T m values obtained for the designed GLP-1 albumin fusions (56.457.4 C) were comparable to that of Tanzeum (58.8 C) (Table 2, Supplementary Fig

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