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Between 1990 and 2022, 89% (177) of all countries had increasing prevalence of obesity in women, and 73% (145) had increasing prevalence in men [2]

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In the HepG2 fatty liver cell model, hypoxia-inducible factor-2alpha (HIF-2)/PPAR pathway was found to be essential for Lira to inhibit liver lipid synthesis and reduce lipid-induced hepatic steatosis [57]