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207.3 PROtocols matter: A systematised evaluation of adherence to Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) patient-reported outcome guidelines in interventional paediatric oncology trials Denise Connolly 1 , Sarah Cohen-Gogo 1 , Sharon De Graves 2 1 The Hospital for Sick Children, Toronto, Ontario, Canada, 2 University of Melbourne, Melbourne, Australia Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :207.3 Aims Despite increasing recognition of their importance, patient-reported outcomes (PROs) remain poorly implemented in interventional paediatric oncology trials

The honest research caveat is that "theoretically additive" is not "experimentally additive" and a researcher who needs to claim synergy must run the combination versus the components in their own model