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GLP-1 drugs, primarily prescribed for type 2 diabetes and weight management, work by enhancing insulin secretion, slowing gastric emptying, and reducing appetite

Stimulating GLP-1R in BMSCs triggers the buildup of nuclear -catenin, which, in turn, activates osteogenic genes by binding with TCF7L12

Hollande et al., 2019

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Additionally, the medications impact on electrolytes - retaining potassium while reducing sodium, magnesium, and calcium - can contribute to muscle weakness and lingering tiredness