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This hormone is also responsible for enhancing insulin sensitivity and regulating blood sugar levels ultimately leading to improved metabolic health and weight control

GPX4-independent antioxidative pathways While the system x c GSHGPX4 axis is acknowledged as the main antilipid peroxidation pathway in ferroptosis, recent studies have identified three GPX4-independent mechanisms that also inhibit ferroptosis: ferroptosis suppressor protein 1 (FSP1)/CoQ10, GTP cyclohydrolase 1 (GCH1)/tetrahydrobiopterin (BH4), and dihydroorotate dehydrogenase (DHODH)

Ethics declarations Data availability The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request

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Gln elicits many beneficial effects in the setting of ischemia-reperfusion