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Summary: Retatrutide should not be combined with insulin or sulfonylureas without medical supervision, and caution is advised with anticoagulants, narrow therapeutic index drugs, other GLP-1 receptor agonists, and supplements with hypoglycaemic properties

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native MGF: ~5-7 minutes ~23 hours (functional, animal data) ~15 hours (implant) ~12 hours (subcutaneous) ~7-8 min free plasma