Med Sci Monit (2019) 25:45539
Microbiotagutbrain axis in the context of bipolar disorder pathophysiology To simplify, the pathophysiological mechanisms by which the MGB axis seems to influence the development of BD are (1) through modulating the enteric and central nervous system (CNS), with a focus on its immunomodulatory actions while influencing the intestinal, systemic and brain inflammation
For example, two 6mg injections instead of one 12mg injection can smooth the concentration curve and reduce nausea peaks
Beyond their well-established benefits in managing type 2 diabetes mellitus (T2DM) and promoting weight reduction, emerging evidence suggests that GLP-1 RAs may also offer neuroprotective, anti-inflammatory, and cardiovascular protective effects 4,5,6,7
With the ongoing obesity epidemic 1,2 and the emergence of promising new pharmacologic agents for obesity such as GLP-1 agonists, 3 providers may be increasingly called upon to consider incorporating weight-loss pharmacotherapy into clinical practice
