However, there have been a few studies that have reported a link between chronic oral ingestion of high doses and the body's intestinal microbiota metabolism, leading to increased TMAO (a compound linked to cardiovascular risk) [7]
Despite this, many refer to them as rebound or withdrawal symptoms
10.1007/s11064-020-03058-3 95 SoltaniM.Hosseinzadeh-AttarM
Low Brain Folate in Autism, Seizures, and Neurological Disorders: Why Its Overlooked and How to Treat It Folate is critical for brain development, neurotransmitter production, and neuroprotection
IL-1Ra knockout in mice led to accelerated IDD, represented by decreased proteoglycan, disrupted collagen structure, increased matrix-degrading enzymes, including MMP3, MMP7, and ADAMTS4, 144 and a higher histological grade of degeneration