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Actinobacteria such as Eggerthella produce hydroxysteroid dehydrogenase (HSDH), which mediates the redox reaction of bile acids, producing various oxidized or isomeric bile acids, promoting Treg cell differentiation, inhibiting Th17 expansion, and maintaining intestinal immune tolerance and homeostasis 146

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The SCALE Kids trial addresses this unmet need to research effective and safe chronic weight loss treatment for this age group6

As awareness of oxidative stress, environmental toxin exposure, and cellular aging mechanisms has expanded, demand for more effective antioxidant delivery systems has intensified correspondingly

TB-500, VIP, and KPV remain in the preclinical stage