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Notably, the prevalence of studies with small sample sizes underscores the imperative for investigations with expansive patient cohorts and prolonged follow-ups to affirm these preliminary insights [20, 46, 69, 80]

Patients and tissue samples We obtained paraffin-embedded samples of primary gastric adenocarcinomas (prepared as Tissue Microarray, TMA) from the Department of Surgery at the Sixth Affiliated Hospital of Sun Yat-sen University

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These exosomes are subsequently activated by cisplatin and paclitaxel, leading to downregulation of ROS levels in gastric cancer cells, inhibition of ferroptosis, and reduced chemotherapy sensitivity[82]